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Lipitor is used for lowering high cholesterol and triglycerides in certain patients.
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Generic brand for atorvastatin, a low-cost cholesterol medicine. The price has skyrocketed. I started asking what caused most of the skyrocketing prices, and answers I heard were all about how big pharma is making a bunch of money off it. That's why the FTC and Department of Justice are going after Johnson and GlaxoSmithKline — because they're trying to monopolize the country's market for cholesterol-lowering drugs.
Now, that is the story you hear most often. But it's not all true. There are ways to have a drug for which the price is so high that it's not competitive. A case in point is drug called Xarelto. Xarelto's manufacturer, Sanofi, announced on Tuesday it's going out of business. Why? Because the patent for drug expires this year. Now Sanofi says the price for Xarelto has suddenly shot up by more than 500%. How would that happen? Here's how. Sanofi patented the drug in 1999 and it patented a generic version of it in 2001. For a year, we heard Sanofi was going to try buy ViiV Healthcare, a New York company, for $6 billion to hold off the patent expirations, and then it would sell the generic version of Xarelto to drug makers. But a big pharma company, Abbott, was apparently unwilling to pay that much, which is why it bought Sanofi.
You might be wondering why Abbott wasn't able to hold off Xarelto from becoming cheaper than Sanofi was. Well, a big reason is that Sanofi had some pretty unusual pricing. As I mentioned, because there was no patent for Xarelto, Xarelto's price couldn't
what is generic for atorvastatin be significantly lowered until Abbott used the patent to lower prices of other existing drugs. So for Atorva 4mg $59.77 - $1 Per pill the last few years as Sanofi held out, Abbott went shopping. Sanofi didn't buy any other drugs. It bought the rights to Xarelto when Abbott wasn't willing to pay enough for it. It then stopped competing against other doctors' offices and drug producers for Xarelto, made a giant fortune off of it. We don't know the exact amount yet, but my estimates put the price of Xarelto at about $1,000 per month, but a little more than $1,000 every six months. Now imagine that Xarelto suddenly became 50-fold more expensive. Imagine the fury of doctors who are forced to switch off of one their most important drugs.
Now that's not the only way to ruin a billion dollar drug. Abbott might be in trouble if it was involved in many other medicines, ranging from Aetna's Humalog to Pfizer's Cialis. A report in New York magazine explains how a drug company purchased several other big-priced drugs from Pfizer that had the same problem; Pfizer's brand-name drug, Viagra, was losing ground to others. Now, Pfizer owns a drug called Levitra, and that's an injection for canada drugstore coupon erectile dysfunction. Pfizer acquired the rights to Levitra in 2001, and the patent on it expired in 2008. Pfizer then started selling Levitra generically, without the patents. There's a version for men who suffer from sexual dysfunction but it has very few advantages over the patent-bearing one. So Pfizer is essentially going out of business. So is all the drug industry. whole thing is an outrage.
So, you see, for pharmaceutical companies like Johnson and (in 2004 it was taken over by Germany's Merck) Xarelto is just one of many products they've bought and patented. They pay big bucks
atorvastatin hexal 20 mg filmtabletten to have it patented and they then hoard up as many patents they can. If the price of their branded drug is much higher than generic alternatives, the company gets all profit for itself. In the case of Johnson and Johnson, this has been shown many times, to the tune of $1.2 billion a year in the wake of patent expirations. So that's how this drug got so expensive. It's not always like this, but drug companies sure are greedy. Even though they make such a huge profit on lot of drugs — they earn $26 billion on generic drugs.
If drug companies were competing on the market for brand-name drugs, there would be competition from multiple companies for one drug. But the drug companies are not allowed to do that. Instead they can only compete for an exclusive rights to a drug, and that means they're likely to make very little profit, if any, off selling that exclusive rights. It's almost impossible to hold one company the cost of making exclusive rights worth it. In the case of Xarelto, it became a $1 billion loss for Sanofi.
So, what's going on in this country? What happens? Well, the big problem is that.
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Generic of lipitor atorvastatin (an atorvastatin-based anticoagulant) and fenofibrate.
Because of concern expressed by some researchers that fenofibrate increases the absorption rate— and risk of bleeding—of warfarin, it used to be prescribed only for the elderly (aged 60 and over). However, the incidence of bleeding has dropped since it entered the U.S. market in 1997. [1] Today, approximately 50 to
Generic accutane brands 60 percent of all patients with the disease use warfarin and 50 to 60 percent of them take warfarin in low doses, according to the manufacturer.
The benefits of atorvastatin (Lipitor) and fenofibrate are the same whether they taken with or alone. When used alone, warfarin lowers LDL cholesterol by increasing "bad" LDL, also referred to as intermediate-density lipoprotein (IDL) cholesterol. Therefore, warfarin is usually prescribed in addition to atorvastatin, order counteract the effect of high LDL levels. It is a double-act: warfarin increases atorvastatin's effectiveness.
When added to other cholesterol-lowering drugs, warfarin can also lower LDL cholesterol to a lesser degree than alone.
Warfarin's effects depend on the dosage, duration, and other medical conditions. For example, a patient taking low dose of warfarin will have more favorable cholesterol-lowering results with a low-dose regimen than more usual dose. The effect of warfarin on LDL is more pronounced when given for short durations (few months to a year), and less when given for longer durations, according to the American Academy of Orthopaedic Surgeons (AAOS).
Fenofibrate can lower LDL cholesterol by decreasing the amount of LDL cholesterol (bad) that circulates in the bloodstream. This decreases risk of heart disease and stroke. When used with warfarin, both drugs work together to decrease the risk of heart disease. This interaction is more pronounced when warfarin used in patients older than 65 years of age, and when it is added as an adjunctive therapy to a lipid-lowering drug that normally is given only to patients younger than 65 years of age.
Warfarin is more likely to interact with angiotensin-converting enzyme (ACE) inhibitors. Warfarin is often used in combination with ACE inhibitors (such as warfarin plus aspirin or lovastatin), as it interacts with the enzyme.
The American College of Cardiology and the Society Critical Care Medicine has published expert panels that monitor warfarin interactions. The FDA receives reports every quarter of new interactions between warfarin and any kind of commonly studied medicine; this type of information is referred to as adverse event reporting. Some new events were identified in 2003, 2006, and 2007, one new adverse event was identified in 2008. [2, 3] The FDA has received 12,947 reports of interactions between warfarin and with coronary artery disease drugs alone, and between warfarin angiotensinogen, the major component of calcium-channel blockers.
Although warfarin does not interact with blood thinners (statins), it is important to make sure that patients on these drugs are taking warfarin with another drug of the class.
With the exception of warfarin plus aspirin, some newer statins are made using fenofibrate, and it is unknown whether they interact with warfarin. Certain medications that are not cholesterol-lowering drugs, such as oral anticoagulants, may also increase the absorption rate and risk of bleeding.
Pregnancy and breast-feeding
For optimal protection against atherosclerotic cardiovascular disease in pregnancy and breastfeeding, patients should receive warfarin without drugs that decrease LDL cholesterol
Cialis generika in deutschland rezeptfrei kaufen or other factors that might affect its ability to protect against disease. If any of the following are true, a woman should not take warfarin:
She takes a medication that increases the absorption rate of warfarin;
She is taking other lipid-lowering medications;
She has blood clots in her legs or lungs;
She has a relative who experienced
atorvastatin basics 20 mg filmtabletten vascular disease;
She has a family history of venous thromboembolism;
She has blood coagulation disorders;
She has an autoimmune disease such as systemic lupus erythematosus (SLE);
She has high or low cholesterol (>300 mg/dL);
She uses a nonsteroidal anti-inflammatory drug or has been diagnosed with a condition associated anticoagulation.
Pregnancy and breast-feeding also involve risks for drug interactions that are important for all patients.
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